https://camelhorsemedrace.com/SALSPRIN Anti-pyretic, anti-thrombotic Non-Steroidal Anti-Inflammatory there is a strong inhibition of the action of the enzyme cyclooxygenase ) in the production of mediators of inflammation. Dexamethasone, on the other hand, inhibits the expression o inhibiting the transcription of the relevant gene and, therefore, reduces the generation of prostaglandins responsible for the symptoms of inflammation._x000D_n_x000D_nRecommendation_x000D_nIt is indicated as an anti-inflammatory, analgesic and antipyretic. It acts on arthritis, tendonitis, rheumatism, congestive processes, hyperthermia, heat stroke and inflammatory complications of traumatic or various microbial conditions._x000D_n_x000D_nFormula_x000D_nEvery 100 mL contains_x000D_nPhenylbutazone…………………………………………….. …..18.00g_x000D_nDexamethasone (sodium phosphate)._x000D_nVehicle eq………………………………………………. ……..100ml_x000D_n_x000D_nHow to use_x000D_nAdult horses: 3 to 4 ml for every 100 kg of body weight, by slow intravenous route, every 24 or 48 hours._x000D_nFoals: 1 to 2 ml for every 50 kg of body weight by slow intravenous route every 24 or 48 hours._x000D_nCattle: 1 to 2 mL for every 100 kg of body mass, by deep intramuscular route, every 48 hours._x000D_nPigs: 0.50 to 1.50 mL for every 50 kg of body weight, intramuscularly (single dose)._x000D_nDogs: 1 mL for every 15 kg of body weight, intravenously slowly, daily. The maximum daily dose should not exceed 800.00 mg._x000D_nDuration of treatment: Use the highest doses for the first 48 hours and then the dose is gradually reduced to a maintenance level and is_x000D_nmaintained at the lowest level capable of achieving a desired clinical response, treatment varies from 3 to 14 days (average of 7 days) in horses and 3 days in SALSPRIN_x000D_n_x000D_nPrecaution_x000D_nPrefer intravenous injections to intramuscular administration as phenylbutazone may cause irritation at the application site._x000D_nInject slowly intravenously at the rate of 10 mL every 30 seconds._x000D_nPhenylbutazone cannot be used in animals intended for human SALSPRIN_x000D_n_x000D_nagainst indication_x000D_nThe use of corticosteroid preparations in acute infectious conditions should be avoided._x000D_n_x000D_nWhen used in non-acute infectious conditions, treatment should be associated with bactericidal antibiotics rather than bacteriostatics._x000D_nIn general, corticosteroids are contraindicated in viral infections and in late pregnancy, when they can induce labor._x000D_n_x000D_nThey should also not be administered to animals that are suffering from renal, cardiac and hepatic insufficiency, gastric ulcer and that present hypersensitivity to the components of the formula. Its use is not recommended in animals with diabetes mellitus, osteoporosis and those with hematocytological alterations (aplastic anemia, leukopenia, agranulocytosis, thrombocytopenia). Do not apply to newborn animals._x000D_n_x000D_ndrug interaction_x000D_nThere are risks of drug interactions occurring when phenylbutazone is administered with other non-steroidal anti-inflammatory agents, as they have a similar mechanism of action (inhibition of cyclooxygenase) and may cause an increase in the occurrence of adverse effects._x000D_nStore in a dry and cool place, protected from light, out of reach of children._x000D_n_x000D_nGrace period_x000D_nDo not consume milk from treated animals within 5 days of the last application and meat within 14 days of the last application._x000D_n_x000D_nSales presentation and shipping
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