ACTH Gel Injection


ACTH Gel Injection- 80IU is frequently used 4-6 hours prior to anticipated exercise. The hormone, ACTH,  stimulates the adrenal gland to secrete large amounts of cortisol into the bloodstream.  This action causes a euphoric response in the brain as well as a potent anti-inflammatory effect at the tissue level.ACTH Gel Injection- 80IU_x000D_nAdrenocorticotropic hormone (ACTH), also known as corticotrophin, is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland.  It is an important component of the hypothalamic pituitary adrenal axis and is often produced in response to biological.  Its principal effects are increased production and release of corticosteroids._x000D_nACTH stimulates secretion of the glucocorticoid steroid hormones from the adrenal cortex cells, especially in the zona fasciculata of adrenal glands.  ACTH acts by binding to cell surface ACTH receptors, which are located primarily on the adrenocortical cells of the adrenal cortex.  The ACTH receptor is a seven membrane spanning G protein- oupled receptor.  Upon ligand binding, the receptor undergoes conformation changes to stimulate the enzyme adenylyl cyclase, which does lead to an increase in intracellular cAMP and subsequent activation of protein kinase.ACTH Gel Injection- 80IU_x000D_nACTH influences steroid hormone secretion by both rapid short term mechanisms that takes place within minutes and slower long term actions.  The rapid actions of ACTH include stimulation of cholesterol delivery to the mitochondria where P450scc enzyme is located.  P450scc catalyzes the first step of steroidogenesis and is cleavage of the side chain of cholesterol.  ACTH also stimulates lipoprotein uptake into the cortical cells.  This increases the bioavailability of cholesterol in cells of the adrenal cortex._x000D_nThe long term actions of ACTH include stimulation of the transcription of the genes coding for steroidogenic enzymes, especially the P450scc, the steroid 11?-hydroxylase along with their associated electron transfer proteins. The effect is observed over several hours._x000D_nIn addition to steroidogenic enzymes, ACTH also enhances transcription of the mitochondrial genes that encode for subunits of mitochondrial oxidative phosphorylation systems.  These actions may actually be necessary to supply the enhanced energy needs of adrenocortical cells stimulated by ACTH.


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